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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MED1 All Species: 26.06
Human Site: T739 Identified Species: 52.12
UniProt: Q15648 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15648 NP_004765.2 1581 168478 T739 T L D T P H I T P A P S Q C S
Chimpanzee Pan troglodytes XP_001172395 1581 168474 T739 T L D T P H I T P A P S Q C S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537654 1583 168625 T739 T L D T P H I T P A P S Q C S
Cat Felis silvestris
Mouse Mus musculus Q925J9 1575 167122 T739 A L D T P H I T P A P S Q C S
Rat Rattus norvegicus NP_001127833 1567 166392 T724 A L D T P H I T P A P S Q C S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521297 422 46589
Chicken Gallus gallus XP_418125 1594 169410 T750 T L D T P H I T P A P S Q C S
Frog Xenopus laevis Q6INP8 1570 165663 T719 A L D T P H I T P A P S Q C G
Zebra Danio Brachydanio rerio XP_700209 1694 176982 I767 G L D T P H S I T P A P S Q C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VP05 1475 149513 C665 K T P N L K H C V S I T P I P
Honey Bee Apis mellifera XP_395879 1811 193227 D882 S P M G P P P D K I P S K Q D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786427 2421 258175 A998 D L T V A N L A K S M S I P A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 98 N.A. 94.4 93.9 N.A. 24.4 87.6 72.5 56.4 N.A. 22 24.4 N.A. 25.7
Protein Similarity: 100 100 N.A. 98.9 N.A. 97.1 96.5 N.A. 25.7 93.5 81.7 69 N.A. 38.9 41.1 N.A. 38.5
P-Site Identity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. 0 100 86.6 33.3 N.A. 0 20 N.A. 13.3
P-Site Similarity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. 0 100 86.6 33.3 N.A. 13.3 33.3 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 25 0 0 0 9 0 0 9 0 59 9 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 0 0 59 9 % C
% Asp: 9 0 67 0 0 0 0 9 0 0 0 0 0 0 9 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 9 0 0 9 0 0 0 0 0 0 0 0 0 0 9 % G
% His: 0 0 0 0 0 67 9 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 59 9 0 9 9 0 9 9 0 % I
% Lys: 9 0 0 0 0 9 0 0 17 0 0 0 9 0 0 % K
% Leu: 0 75 0 0 9 0 9 0 0 0 0 0 0 0 0 % L
% Met: 0 0 9 0 0 0 0 0 0 0 9 0 0 0 0 % M
% Asn: 0 0 0 9 0 9 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 9 9 0 75 9 9 0 59 9 67 9 9 9 9 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 59 17 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 9 0 0 0 0 0 9 0 0 17 0 75 9 0 50 % S
% Thr: 34 9 9 67 0 0 0 59 9 0 0 9 0 0 0 % T
% Val: 0 0 0 9 0 0 0 0 9 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _